The A35 is closed in both directions due to a two-vehicle crash.
The incident happened between Hayne Lane (Wilmington) and Pine Park Road (Honiton).
There are heavy traffic delays on the A35 Exeter Road to A375 Sidmouth Road.
Diversions are in place with eastbound traffic to follow route of A30, A303 and A358 to reach Axminster.
Westbound traffic to follow the same route in reverse.
There are also reports of a second accident, again involving two cars, on the A358 Musbury Road near Gamberlake.
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